The popularity of nicotinamide adenine dinucleotide (NAD) supplements is growing as individuals seek ways to support their journey toward healthy aging. NAD, a vital coenzyme involved in cellular energy production, holds great potential for several health benefits. It helps maintain cellular health, increases energy levels, and promotes brain wellness.
As we age, NAD levels naturally decline, leading to decreased cellular energy production and a general decline in overall health. However, studies have shown that supplementation with NAD can effectively counteract this age-related decline and improve cellular health.
In addition, NAD supplements have been shown to increase energy levels and improve cognitive function. Most importantly, emerging evidence suggests that these supplements may provide a shield against age-related brain damage. Today, we delve into the realm of premium NAD-boosting supplements and explore their role in promoting cellular health. Stay tuned for more insights.
By providing an introduction to the topic and presenting our three top picks for NAD+ supplements, we have conducted extensive research to compile a list of the best NAD+ supplements for 2023. Our article aims to provide you with all the relevant information you need to know about NAD+ to ensure a comprehensive understanding of the subject.
Best Product: GenF20 Liposomal NMN
GenF20 Liposomal NMN+ is a highly respected manufacturer specializing in the production of premium NMN capsules. Their capsules are notable for being gluten-free, GMO-free, additive-free, preservative-free, soy-free, and dairy-free. Manufactured to strict GMP and U.S. standards, these capsules undergo rigorous third-party laboratory testing at every stage of production. They are also regulated by the FDA to ensure safety and efficacy.
An outstanding feature of Liposomal NMN+ capsules is their high antioxidant content, which supports healthy NAD+ levels and effectively slows the aging process. In addition to their commitment to quality products, Liposomal NMN+ offers rewards and loyalty programs for customers, allowing them to earn redeemable points through referrals or subscription length.
When it comes to pricing, GenF20 Liposomal NMN offers competitive pricing, ranging from $58.95 to $69.95 for their products. With a 500mg bottle priced at $1 per count and a 300mg bottle priced at $2 per count, this product undoubtedly emerges as our top choice in our review process!
Manufacturer: GenF20 Liposomal NMN
Pros: Top Ingredients, money back guarantee, highly effective, independently tested
Second Place: PartiQlar
Step into the extraordinary realm of PartiQlar NMN and discover the limitless possibilities that lie ahead. Prepare yourself for a transformative journey full of remarkable experiences and profound benefits. PartiQlar NMN is no ordinary product; it serves as a catalyst for positive change and embodies excellence.
Heralding a new era of vitality and wellness, PartiQlar Pure NMN exceeds all expectations. This exceptional product is meticulously formulated to increase energy levels, promote rejuvenation, and optimize overall health. With its unparalleled composition, PartiQlar NMN stands at the forefront of health supplements, delivering a distinctive blend of efficacy and innovation.
Immerse yourself in the wonders of PartiQlar Pure NMN and witness a newfound vitality permeate every facet of your life. Embrace the invigorating sensation as your energy soars and mental clarity sharpens. Say goodbye to exhaustion and embrace a life filled with renewed vitality, productivity and enthusiasm. PartiQlar NMN is not just a product; it serves as a gateway to a revitalized version of yourself.
In summary, PartiQlar NMN secures second place among the best NAD+ supplements due to its exceptional formulation, innovative approach, and remarkable impact on vitality and overall well-being.
Pros: Delays aging, boosts energy levels, improves endurance & strenght
Third Place: Hello100 Liposomal NMN+
Hello100, a US-based company, manufactures its liposomal NMN supplements locally under both GMP and HACCP standards. These superior capsules of plant-based nicotinamide mononucleotide each contain 100 mg of liposomal NMN.
The integration of liposomal technology enhances the bioavailability of the supplement, ensuring that the desired amount of NMN is effectively absorbed into cells and tissues. In addition to 95% pure NMN, each capsule of Hello100 contains four other ingredients: TMG (betaine), trans-resveratrol, vitamin B12 and folic acid (vitamin B9).
For maximum effectiveness, Hello100 recommends taking two capsules a day: one in the morning before meals and one in the afternoon to synchronise NAD+ levels with the body's internal clock. Although Hello100 offers free domestic shipping, there is currently no recurring subscription system. However, significant discounts are offered to both returning and first-time customers.
Hello100's NMN supplements can be purchased in 1, 3 or 6 month supplies, all backed by a 60 day refund policy.
Pros: Plant-based, GMP and HACCP standards, Money-back guarantee
Fourth Place: Wonderfeel Youngr
Youngr NMN, a supplement by Wonderfeel, ranks third among the best NAD+ supplements, offering support for healthy aging through the inclusion of antioxidants, sirtuin activators, and a generous dose of 900mg NMN. Users have reported a variety of benefits, including increased energy levels, improved memory, increased skin elasticity, and improved sleep quality. In order to maximize the bioavailability of Resveratrol and slow down the aging process, it is recommended that this supplement be taken in the morning along with high-fat, nutritious foods.
Wonderfeel is currently offering an introductory price for both subscription plans and one-time purchases, allowing customers to save $15 and lock in the price. For further insight into the product, the Wonderfeel website offers access to customer reviews that provide valuable information.
While NMN supplements offer remarkable benefits, it is important to remember that they are not a substitute for medical treatment. Regular check-ups with a healthcare provider are still recommended to ensure optimal health and well-being.
Pros: Formula developed by a Harvard MD, improved energy levels, enhanced memory function and increased skin elasticity.
Cons: Size options limited
Fifth Place: Quicksilver NAD+
QuickSilver NMN ranks fourth among the best NAD+ supplements, just missing our top three selections. The supplement is regularly tested by third-party laboratories to ensure purity and stability.
What sets QuickSilver NMN apart is its unique formulation, which incorporates platinum and special liposomal technology that mimics the transport of NMN within the body. This innovative approach ensures that essential components are delivered to the exact locations where they can be efficiently utilized. The supplement's liquid consistency promotes high absorption, maximizing its effectiveness.
In addition, QuickSilver NMN contains vitamin B12, which helps maintain blood and nerve cells, and riboflavin, known for its anti-inflammatory properties and ability to slow the aging process while providing antioxidant benefits.
While QuickSilver NMN offers notable features and ingredients, it did not secure a spot in our top three due to factors such as overall customer feedback and its standing compared to other top performing NAD+ supplements.
Pros: GMO free & vegan friendly. Third-party tested and uses liposome technology. Excellent reviews for this product.
Cons: The products must be refrigerated immediately after purchase and have a no-return policy for unsatisfactory or damaged items.
Sixth Place: OMRE NMN
Omre NMN, while a remarkable NAD+ supplement, secures sixth place in our ranking of the best NAD+ supplements, narrowly missing out on our top three selections. The supplement undergoes rigorous purity and safety testing throughout its manufacturing process, with independent laboratories conducting comprehensive evaluations.
Priced at $4.05 per gram, Omre NMN offers a 60-count bottle of 300mg capsules at a discounted price of $42.57 on Amazon, originally priced at $44.80. While Omre offers several discounts and benefits, purchasing in bulk may not always result in savings.
To accommodate different customer preferences and needs, Omre offers multiple pricing and shipping options. Orders over $75 qualify for free shipping, while orders under $75 incur a shipping fee of $4.99 for first class shipping or $12 for FedEx shipping, which guarantees delivery within two days.
Omre takes product quality and safety very seriously, as evidenced by their commitment to extensive testing. By offering a variety of pricing and shipping options, the company strives to accommodate a range of customer preferences.
Overall, while Omre NMN offers commendable product quality and diverse options, factors such as pricing and overall customer feedback prevented it from securing a spot in our top three.
Pros: The supplement is highly absorbable and free of chemical solvents or artificial additives, 30-day money back guarantee.
Cons: Unfortunately, this product is not available for purchase online, and information regarding third-party testing and results is not currently available.
Seventh Place: Double Wood
Securing the sixth and final position among the best NAD+ supplements, this product did not make our top three selections. While it is made in the USA with high-quality ingredients and has undergone rigorous third-party lab testing to ensure purity and potency, several factors influenced its placement.
Recommended daily doses of NMN typically range from 250 mg to 1500 mg; however, this brand's products only offer doses ranging from 250 mg to 500 mg. A 250 mg dose can be achieved by taking one 125 mg capsule in the morning and one in the afternoon, or by taking additional 125 mg capsules one to three hours apart for higher doses.
For new customers, a 60-count bottle of 125 mg capsules is priced at $48.95. Returning customers and new subscribers can purchase it at a discounted price of $43.08. While this product offers a viable option for individuals seeking lower dosage ranges, it did not secure a spot in our top three due to factors such as dosage options, overall customer feedback, and competitive alternatives.
Manufacturer: Double Wood
Pros: GMO and Gluten Free, Third Party Labs Tested, FDA Regulated
Cons: Not widely available, not affordable
What is NAD+?
Nicotinamide adenine dinucleotide, commonly known as NAD, plays a critical role in our bodies. As a coenzyme, it is intimately involved in the optimal functioning of mitochondria, often referred to as the cellular powerhouses. Increased mitochondrial efficiency translates into improved cellular performance and waste elimination, which affects various bodily systems. The remarkable aspect of NAD is its ability to address multiple areas without the need for numerous supplements.
Within the realm of NAD, NAD+ stands out. While some supplements contain NAD+ as a primary ingredient, our understanding of NAD+ metabolism suggests that its bioavailability is limited when compared to its precursors, NMN and NR. By using these NAD+ precursors instead of NAD+ itself, a greater amount of NAD+ is made available in the body. However, the safest and most effective precursor is controversial. To understand the conversion of vitamin B3 to NAD+ in the body, it is important to understand the function of each precursor.
The Scientific Benefits of NAD
If you are looking for a natural approach to improving your skin's well-being, consider exploring the potential of NAD (nicotinamide adenine dinucleotide), a vital vitamin-like compound found in every cell of your body. NAD plays a critical role in cellular energy metabolism and provides support for optimal skin function. Let's take a closer look at the scientifically proven benefits of NAD for skin health.
Improve hydration levels
When incorporated into oral supplements or topical treatments, NAD helps to increase skin hydration at the surface level, thereby reducing the appearance of wrinkles, fine lines and other signs of aging caused by dehydration. In a study of middle-aged women, those who received NAD supplementation experienced significant improvements in skin hydration compared to those who did not receive supplementation.
Immunity Boost Against Skin Infections
Notably, NAD has immune-boosting properties that extend to skin health. It helps fight bacterial infections commonly seen in people with acne or specific skin conditions such as oily or dry complexions. In addition, NAD's ability to stimulate cell formation reduces existing inflammation and redness caused by breakouts, providing welcome relief for those prone to such concerns.
Repairing sun damage
NAD has been shown to be effective in repairing sun-induced skin damage. Topical application as part of a skin care regimen accelerates the regeneration of skin layers by activating protein molecules known as sirtuins, which regulate gene expression and DNA repair. In addition, NAD helps protect against further ultraviolet (UV) exposure by counteracting the free radicals generated when UV radiation interacts with the skin.
Increase collagen production
NAD supplementation promotes optimal hydration levels in the skin and stimulates the synthesis of collagen, a protein essential for maintaining smoothness and elasticity over time. Since the body naturally produces less collagen as we age, NAD supplementation helps maintain this essential process, preserving a more youthful appearance for longer.
Reducing inflammation and oxidative stress
NAD helps reduce inflammation and oxidative stress, two factors that contribute to premature aging, wrinkles and other visible signs of aging skin. Studies suggest that increasing NAD levels may protect cells from age-related damage, including that caused by sun exposure and environmental toxins.
Effectiveness of NAD+ Supplements
Clinical studies have provided compelling evidence of the remarkable efficacy of NAD+ supplements. These supplements have demonstrated significant health benefits in humans and other mammals, particularly in the management of age-related conditions. Of the known NAD+ precursors, NMN and NR both share the common goal of increasing NAD+ levels. However, their efficacy and safety profiles differ.
Recent research suggests that while NR can increase NAD+ levels, its stability issues result in its degradation to NAM (nicotinamide), another precursor of NAD+. Prolonged overexpression of NAM has the potential to induce genomic instability, albeit in rare cases. In addition, the conversion of NR to NAD+ requires two additional steps, resulting in a comparatively slower onset of action.
In contrast, NMN has demonstrated safety and tolerability in human and mammalian studies. In particular, doses greater than 1000 mg of NMN have shown no adverse effects while promoting increased expression of longevity genes. In addition, NMN is only one conversion step away from becoming NAD+, requiring less energy and a shorter conversion time.
While some individuals may opt for the more affordable powder form of these supplements, it is important to note that a significant portion of the powder is destroyed by stomach acid and does not enter the bloodstream. For optimal effectiveness, liposomal capsules and sublingual NAD+ supplements are considered the most efficient delivery methods.
Common Ingredients Found in NAD Boosters to Improve Skin Health
NAD boosters have recently gained considerable attention in the skin care field, but their exact nature and mechanisms remain the subject of ongoing research. This article examines the additional ingredients commonly found in NAD boosters and their role in promoting healthier skin.
Green Coffee Bean, derived from unroasted coffee beans, retains chlorogenic acid (CGA), an essential compound with powerful antioxidant properties. CGA helps neutralize free radicals in the body, promoting healthier skin tone, improved metabolism, and better regulation of blood sugar levels. In addition, green coffee beans support metabolic functions by increasing fatty acid oxidation, potentially leading to fat loss and facilitating the attainment of desired body shape.
The presence of caffeine in green coffee beans also provides an energy boost to combat low motivation and fatigue. In addition, CGA's antioxidant properties make green coffee beans effective in combating cell damage caused by environmental toxins, thus preventing premature signs of aging such as wrinkles, dryness and age spots.
Apigenin 98%, a water-soluble flavone compound derived from various sources such as herbs, vegetables, fruits and chamomile tea, is used as a dietary supplement and cosmetic ingredient for its anti-aging properties. By inhibiting pro-inflammatory pathways and modulating cytokine production, Apigenin-98% reduces cellular damage to skin tissue, thereby counteracting signs of aging such as wrinkles, sagging skin and hyperpigmentation. This ingredient also acts as a powerful antioxidant, fighting free radicals (common culprits of aging) and stimulating collagen production, further enhancing the skin's youthful appearance. By reducing inflammatory responses and aiding cell regeneration, Apigenin reduces redness and inflammation, helping the skin to heal.
Niacin, also known as vitamin B3, plays a vital role in human biology, aiding in the synthesis of essential compounds such as fatty acids, proteins, hormones and enzymes. Occurring naturally in various food sources such as fish, beef, poultry, mushrooms and multivitamins, niacin shows commendable benefits when applied topically. It shields the skin from environmental stressors such as sun exposure and pollution, increases circulation to provide an oxygen boost for improved cell turnover, and exhibits anti-inflammatory properties that reduce irritation while stimulating collagen production.
In addition, niacin's contribution to liver health is noteworthy, as the liver plays a critical role in detoxification, thereby promoting healthier-looking skin. In addition, niacin, when taken in the form of supplements such as NAD, possesses properties essential for the establishment of new hair follicles, resulting in thicker and healthier hair growth, making it an important factor in addressing hair thinning issues.
Green Tea Extract, a concentrated form of the active compounds found in green tea leaves, offers numerous potential anti-aging benefits. Rich in antioxidants and polyphenols, it has been associated with reduced risk of cancer and heart disease, improved cognitive function, digestive health, bone strength, improved metabolism, and potentially increased longevity. The polyphenols, particularly catechins, found in green tea extract scavenge free radicals, preventing oxidative damage and reducing signs of aging.
In addition, catechins may protect against UVB radiation damage, which contributes to aging symptoms such as wrinkles, sagging skin, and discoloration. Notably, green tea polyphenols exhibit remarkable anti-inflammatory properties, potentially reducing inflammation associated with age-related conditions such as arthritis. In addition, green tea's neuroprotective effects are being studied, suggesting that it may support better brain health by protecting neurons from oxidative stress.
Used in a variety of ways, silicon dioxide helps to enhance the anti-aging effects of skin care. Its effectiveness lies in reducing the appearance of wrinkles and fine lines, while protecting the skin from future damage and maintaining a youthful appearance. Amorphous Silica, the dominant form of silicon dioxide used in skin care products, forms a protective film on the skin's surface. This film not only retains moisture, but also acts as a barrier against harsh external irritants such as dirt, oil, smog and pollutants that accelerate premature aging.
In addition, the silica particles have remarkable antioxidant properties that fight the signs of aging on contact with the skin. These antioxidants effectively neutralize existing free radicals on the skin's surface, preventing damage to healthy cells. The result is a more harmonious complexion, with wrinkles and discolorations caused by sun damage or acne scars gradually diminishing over time.
Are NAD+ supplements safe to take?
The safety of NAD+ supplements is currently under investigation. In the short term, these supplements appear to be generally safe and well tolerated. However, it's worth noting that, similar to other forms of vitamin B, certain side effects such as flushing and digestive problems may occur with the use of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), although these side effects are rare and usually mild in nature.
At present, there is a lack of long-term studies examining the safety of NR and NMN. Our understanding of NAD+ is still incomplete. While the supplement industry often promotes NAD+ as a potential fountain of youth, cancer researchers have demonstrated success in inhibiting tumor growth by limiting NAD+ availability in patients.
It remains plausible that NAD+ could delay the onset of age-related conditions while potentially facilitating the growth of cancer cells in the body. Given the current uncertainties, it is prudent to approach NAD+ supplementation with caution. It is wise to consult with a health care professional before beginning NAD+ supplementation, especially if there is a personal or family history of cancer.
Possible Side Effects of Taking NAD+ Supplements
While NAD+ supplements are generally safe, high doses of these NAD+ precursors may cause some adverse effects, including
- upset stomach
- Mild headache
It is advisable to consult with a healthcare professional before starting any supplement, especially if you have any underlying medical conditions. NAD+ supplements may interact with prescription medications, and professional guidance is necessary to ensure safety and efficacy.
Methods to Increase NAD+ Levels Naturally
In addition to supplementation, there are natural ways to boost NAD+ levels as recommended by longevity experts:
- Consider intermittent fasting or maintaining a low-calorie diet, as these practices may help stabilize NAD+ levels without directly increasing them.
- Engage in regular exercise, which may not directly increase NAD+ levels but can stabilize ATP production, the primary source of cellular energy.
- Include NMN-rich foods in your diet.
- Consume foods rich in vitamin B3, such as milk, whole grains, fish, and yeast.
Frequently Asked Questions (FAQ)
What health benefits can NAD supplements provide?
NAD supplements provide a number of health benefits, including support for cellular health and the aging process. They play a critical role in cellular energy production and contribute to DNA repair.
Since NAD levels naturally decline with age, maintaining healthy levels is important for maintaining cognitive function and promoting healthy aging. NAD supplements can aid in cellular repair and protect against damage caused by oxidative stress.
Are NAD+ supplements considered safe?
Yes, NAD+ supplements, including NMN and NR, are generally safe and well tolerated. There are no significant adverse effects when taken in optimal doses.
Can NAD Boosters cause any side effects?
Although side effects may vary depending on the specific NAD Booster used, they are generally mild and temporary. Common side effects include headaches, fatigue, gastrointestinal upset, and skin irritation, which usually subside within a few days of starting supplementation.
In rare cases, lower quality products can cause more serious side effects such as liver damage and allergic reactions. It is important to note that such serious side effects are typically associated with products that do not use clinically proven ingredients.
Do NAD+ supplements really work?
In fact, clinical studies and user feedback indicate the efficacy of NAD+ supplements. However, individual responses to supplements can vary, and benefits may manifest over time or be detected by blood tests.
Are NAD+ supplements different from NMN supplements?
NAD+ supplements include NMN, NR and other precursor molecules. Some supplements contain NAD+ molecules as well. While they provide similar benefits, NAD+ supplements and NMN supplements differ in size and absorption rate.
How can NAD levels be increased naturally?
NAD levels naturally decline with age, but there are ways to support and prevent a rapid decline. Eating a healthy diet rich in fruits, vegetables, and whole grains provides antioxidants that protect cells and reduce inflammation.
Regular exercise, including moderate exercise and high-intensity interval training, increases blood flow and cellular energy production, thereby boosting NAD levels. Getting enough sleep is also important, as sleep deprivation can lead to decreased NAD levels.
Which Brand Offers the Best NAD+ Supplements?
While there is no one-size-fits-all answer, our market research suggests that GenF20 NMN stands out as an excellent NAD+ supplement for promoting healthy aging. This brand offers high purity, bioavailable supplements in safe doses.
In summary, maintaining adequate levels of nicotinamide adenine dinucleotide (NAD) is critical for optimal cellular function. As we age, NAD+ levels naturally decline, leading to various age-related problems. While there are natural methods to increase NAD+ levels, there is also the option of using nicotinamide riboside (NR) supplements.
Supplementation with NAD can result in increased energy levels. In addition, nicotinamide riboside supplements offer potential health benefits, including the reversal of age-related conditions and support for graceful aging. It is important to note that individual experiences may vary, and it is advisable to consult with a healthcare professional before incorporating any supplements into your routine.
- Zettler, P. J., Guerrini, C. J., & Sherkow, J. S. (2019). Regulating genetic biohacking. Science (New York, N.Y.), 365(6448), 34.
- Wu, L. E., & Sinclair, D. A. (2019). The elusive NMN transporter is found. Nature Metabolism, 1(1), 8-9.
- Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., & Migaud, M. E. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolism, 1(1), 47.
- McCormack, D., & McFadden, D. (2012). A Review of Pterostilbene Antioxidant Activity and Disease Modification. Oxidative Medicine and Cellular Longevity, 2013.
- Madunić, J., Madunić, I. V., Gajski, G., Popić, J., & Garaj-Vrhovac, V. (2018). Apigenin: A dietary flavonoid with diverse anticancer properties. Cancer Letters, 413, 11–22.
- Zeisel, S. H. (2017). Choline, Other Methyl-Donors and Epigenetics. Nutrients, 9(5).
- Sun, Y., Qin, H., Zhang, H., Feng, X., Yang, L., Hou, X., & Chen, J. (2020). Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food & Nutrition Research, 65.
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