Best NAD+ Supplements – Reviews, Experience, Test & Evaluation 2024

What is NAD+?

Nicotinamide adenine dinucleotide, commonly known as NAD, plays a critical role in our bodies. As a coenzyme, it is intimately involved in the optimal functioning of mitochondria, often referred to as the cellular powerhouses. Increased mitochondrial efficiency translates into improved cellular performance and waste elimination, which affects various bodily systems. The remarkable aspect of NAD is its ability to address multiple areas without the need for numerous supplements.

Within the realm of NAD, NAD+ stands out. While some supplements contain NAD+ as a primary ingredient, our understanding of NAD+ metabolism suggests that its bioavailability is limited when compared to its precursors, NMN and NR. By using these NAD+ precursors instead of NAD+ itself, a greater amount of NAD+ is made available in the body. However, the safest and most effective precursor is controversial. To understand the conversion of vitamin B3 to NAD+ in the body, it is important to understand the function of each precursor.

The Scientific Benefits of NAD

If you are looking for a natural approach to improving your skin's well-being, consider exploring the potential of NAD (nicotinamide adenine dinucleotide), a vital vitamin-like compound found in every cell of your body. NAD plays a critical role in cellular energy metabolism and provides support for optimal skin function. Let's take a closer look at the scientifically proven benefits of NAD for skin health.

Improve hydration levels
When incorporated into oral supplements or topical treatments, NAD helps to increase skin hydration at the surface level, thereby reducing the appearance of wrinkles, fine lines and other signs of aging caused by dehydration. In a study of middle-aged women, those who received NAD supplementation experienced significant improvements in skin hydration compared to those who did not receive supplementation.

Immunity Boost Against Skin Infections
Notably, NAD has immune-boosting properties that extend to skin health. It helps fight bacterial infections commonly seen in people with acne or specific skin conditions such as oily or dry complexions. In addition, NAD's ability to stimulate cell formation reduces existing inflammation and redness caused by breakouts, providing welcome relief for those prone to such concerns.

Repairing sun damage
NAD has been shown to be effective in repairing sun-induced skin damage. Topical application as part of a skin care regimen accelerates the regeneration of skin layers by activating protein molecules known as sirtuins, which regulate gene expression and DNA repair. In addition, NAD helps protect against further ultraviolet (UV) exposure by counteracting the free radicals generated when UV radiation interacts with the skin.

Increase collagen production
NAD supplementation promotes optimal hydration levels in the skin and stimulates the synthesis of collagen, a protein essential for maintaining smoothness and elasticity over time. Since the body naturally produces less collagen as we age, NAD supplementation helps maintain this essential process, preserving a more youthful appearance for longer.

Reducing inflammation and oxidative stress
NAD helps reduce inflammation and oxidative stress, two factors that contribute to premature aging, wrinkles and other visible signs of aging skin. Studies suggest that increasing NAD levels may protect cells from age-related damage, including that caused by sun exposure and environmental toxins.

Effectiveness of NAD+ Supplements

Clinical studies have provided compelling evidence of the remarkable efficacy of NAD+ supplements. These supplements have demonstrated significant health benefits in humans and other mammals, particularly in the management of age-related conditions. Of the known NAD+ precursors, NMN and NR both share the common goal of increasing NAD+ levels. However, their efficacy and safety profiles differ.

Recent research suggests that while NR can increase NAD+ levels, its stability issues result in its degradation to NAM (nicotinamide), another precursor of NAD+. Prolonged overexpression of NAM has the potential to induce genomic instability, albeit in rare cases. In addition, the conversion of NR to NAD+ requires two additional steps, resulting in a comparatively slower onset of action.

In contrast, NMN has demonstrated safety and tolerability in human and mammalian studies. In particular, doses greater than 1000 mg of NMN have shown no adverse effects while promoting increased expression of longevity genes. In addition, NMN is only one conversion step away from becoming NAD+, requiring less energy and a shorter conversion time.

While some individuals may opt for the more affordable powder form of these supplements, it is important to note that a significant portion of the powder is destroyed by stomach acid and does not enter the bloodstream. For optimal effectiveness, liposomal capsules and sublingual NAD+ supplements are considered the most efficient delivery methods.

Common Ingredients Found in NAD Boosters to Improve Skin Health

NAD boosters have recently gained considerable attention in the skin care field, but their exact nature and mechanisms remain the subject of ongoing research. This article examines the additional ingredients commonly found in NAD boosters and their role in promoting healthier skin.

Green Coffee Bean, derived from unroasted coffee beans, retains chlorogenic acid (CGA), an essential compound with powerful antioxidant properties. CGA helps neutralize free radicals in the body, promoting healthier skin tone, improved metabolism, and better regulation of blood sugar levels. In addition, green coffee beans support metabolic functions by increasing fatty acid oxidation, potentially leading to fat loss and facilitating the attainment of desired body shape.

The presence of caffeine in green coffee beans also provides an energy boost to combat low motivation and fatigue. In addition, CGA's antioxidant properties make green coffee beans effective in combating cell damage caused by environmental toxins, thus preventing premature signs of aging such as wrinkles, dryness and age spots.

Apigenin 98%, a water-soluble flavone compound derived from various sources such as herbs, vegetables, fruits and chamomile tea, is used as a dietary supplement and cosmetic ingredient for its anti-aging properties. By inhibiting pro-inflammatory pathways and modulating cytokine production, Apigenin-98% reduces cellular damage to skin tissue, thereby counteracting signs of aging such as wrinkles, sagging skin and hyperpigmentation. This ingredient also acts as a powerful antioxidant, fighting free radicals (common culprits of aging) and stimulating collagen production, further enhancing the skin's youthful appearance. By reducing inflammatory responses and aiding cell regeneration, Apigenin reduces redness and inflammation, helping the skin to heal.

Niacin, also known as vitamin B3, plays a vital role in human biology, aiding in the synthesis of essential compounds such as fatty acids, proteins, hormones and enzymes. Occurring naturally in various food sources such as fish, beef, poultry, mushrooms and multivitamins, niacin shows commendable benefits when applied topically. It shields the skin from environmental stressors such as sun exposure and pollution, increases circulation to provide an oxygen boost for improved cell turnover, and exhibits anti-inflammatory properties that reduce irritation while stimulating collagen production.

In addition, niacin's contribution to liver health is noteworthy, as the liver plays a critical role in detoxification, thereby promoting healthier-looking skin. In addition, niacin, when taken in the form of supplements such as NAD, possesses properties essential for the establishment of new hair follicles, resulting in thicker and healthier hair growth, making it an important factor in addressing hair thinning issues.

Green Tea Extract, a concentrated form of the active compounds found in green tea leaves, offers numerous potential anti-aging benefits. Rich in antioxidants and polyphenols, it has been associated with reduced risk of cancer and heart disease, improved cognitive function, digestive health, bone strength, improved metabolism, and potentially increased longevity. The polyphenols, particularly catechins, found in green tea extract scavenge free radicals, preventing oxidative damage and reducing signs of aging.

In addition, catechins may protect against UVB radiation damage, which contributes to aging symptoms such as wrinkles, sagging skin, and discoloration. Notably, green tea polyphenols exhibit remarkable anti-inflammatory properties, potentially reducing inflammation associated with age-related conditions such as arthritis. In addition, green tea's neuroprotective effects are being studied, suggesting that it may support better brain health by protecting neurons from oxidative stress.

Used in a variety of ways, silicon dioxide helps to enhance the anti-aging effects of skin care. Its effectiveness lies in reducing the appearance of wrinkles and fine lines, while protecting the skin from future damage and maintaining a youthful appearance. Amorphous Silica, the dominant form of silicon dioxide used in skin care products, forms a protective film on the skin's surface. This film not only retains moisture, but also acts as a barrier against harsh external irritants such as dirt, oil, smog and pollutants that accelerate premature aging.

In addition, the silica particles have remarkable antioxidant properties that fight the signs of aging on contact with the skin. These antioxidants effectively neutralize existing free radicals on the skin's surface, preventing damage to healthy cells. The result is a more harmonious complexion, with wrinkles and discolorations caused by sun damage or acne scars gradually diminishing over time.

Are NAD+ supplements safe to take?

The safety of NAD+ supplements is currently under investigation. In the short term, these supplements appear to be generally safe and well tolerated. However, it's worth noting that, similar to other forms of vitamin B, certain side effects such as flushing and digestive problems may occur with the use of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), although these side effects are rare and usually mild in nature.

At present, there is a lack of long-term studies examining the safety of NR and NMN. Our understanding of NAD+ is still incomplete. While the supplement industry often promotes NAD+ as a potential fountain of youth, cancer researchers have demonstrated success in inhibiting tumor growth by limiting NAD+ availability in patients.

It remains plausible that NAD+ could delay the onset of age-related conditions while potentially facilitating the growth of cancer cells in the body. Given the current uncertainties, it is prudent to approach NAD+ supplementation with caution. It is wise to consult with a health care professional before beginning NAD+ supplementation, especially if there is a personal or family history of cancer.

Possible Side Effects of Taking NAD+ Supplements

While NAD+ supplements are generally safe, high doses of these NAD+ precursors may cause some adverse effects, including

• Fatigue
• diarrhea
• Nausea
• upset stomach
• Mild headache

It is advisable to consult with a healthcare professional before starting any supplement, especially if you have any underlying medical conditions. NAD+ supplements may interact with prescription medications, and professional guidance is necessary to ensure safety and efficacy.

Methods to Increase NAD+ Levels Naturally

In addition to supplementation, there are natural ways to boost NAD+ levels as recommended by longevity experts:

• Consider intermittent fasting or maintaining a low-calorie diet, as these practices may help stabilize NAD+ levels without directly increasing them.
• Engage in regular exercise, which may not directly increase NAD+ levels but can stabilize ATP production, the primary source of cellular energy.
• Include NMN-rich foods in your diet.
• Consume foods rich in vitamin B3, such as milk, whole grains, fish, and yeast.

Frequently Asked Questions (FAQ)

What health benefits can NAD supplements provide?
NAD supplements provide a number of health benefits, including support for cellular health and the aging process. They play a critical role in cellular energy production and contribute to DNA repair.

Since NAD levels naturally decline with age, maintaining healthy levels is important for maintaining cognitive function and promoting healthy aging. NAD supplements can aid in cellular repair and protect against damage caused by oxidative stress.

Are NAD+ supplements considered safe?
Yes, NAD+ supplements, including NMN and NR, are generally safe and well tolerated. There are no significant adverse effects when taken in optimal doses.

Can NAD Boosters cause any side effects?
Although side effects may vary depending on the specific NAD Booster used, they are generally mild and temporary. Common side effects include headaches, fatigue, gastrointestinal upset, and skin irritation, which usually subside within a few days of starting supplementation.

In rare cases, lower quality products can cause more serious side effects such as liver damage and allergic reactions. It is important to note that such serious side effects are typically associated with products that do not use clinically proven ingredients.

Do NAD+ supplements really work?
In fact, clinical studies and user feedback indicate the efficacy of NAD+ supplements. However, individual responses to supplements can vary, and benefits may manifest over time or be detected by blood tests.

Are NAD+ supplements different from NMN supplements?
NAD+ supplements include NMN, NR and other precursor molecules. Some supplements contain NAD+ molecules as well. While they provide similar benefits, NAD+ supplements and NMN supplements differ in size and absorption rate.

How can NAD levels be increased naturally?
NAD levels naturally decline with age, but there are ways to support and prevent a rapid decline. Eating a healthy diet rich in fruits, vegetables, and whole grains provides antioxidants that protect cells and reduce inflammation.

Regular exercise, including moderate exercise and high-intensity interval training, increases blood flow and cellular energy production, thereby boosting NAD levels. Getting enough sleep is also important, as sleep deprivation can lead to decreased NAD levels.

Which Brand Offers the Best NAD+ Supplements?
While there is no one-size-fits-all answer, our market research suggests that GenF20 NMN stands out as an excellent NAD+ supplement for promoting healthy aging. This brand offers high purity, bioavailable supplements in safe doses.

Conclusion

In summary, maintaining adequate levels of nicotinamide adenine dinucleotide (NAD) is critical for optimal cellular function. As we age, NAD+ levels naturally decline, leading to various age-related problems. While there are natural methods to increase NAD+ levels, there is also the option of using nicotinamide riboside (NR) supplements.

Supplementation with NAD can result in increased energy levels. In addition, nicotinamide riboside supplements offer potential health benefits, including the reversal of age-related conditions and support for graceful aging. It is important to note that individual experiences may vary, and it is advisable to consult with a healthcare professional before incorporating any supplements into your routine.