Diarrhoeal illness is a leading cause of child mortality and morbidity worldwide. There are no precise or current estimates of the types and prevalence of pathogens associated with diarrheal illnesses in developed and developing settings. This systematic review assessed data from 60 studies published in the English language from five developing regions and developed countries worldwide to provide regional estimates of enteric pathogens affecting children. The random-effect method was used to establish the weighted average prevalence of pathogens in adults and children for each region. Significantly more pathogens were reported by studies from developing regions compared with Organisation for Economic Co-operation and Development countries (P<0.016). The identification rates of pathogens from community based and hospital based studies were similar (58.5% and 58.1% respectively, P<0.619). The overall detection of enteric pathogens in developing countries was higher in adults (74.8%; 95% CI 63.1-83.8%) compared with children (56.7%; 95% CI 53.0-60.4%) (P<0.001). Rotavirus was the most frequently detected pathogen in all regions with the highest rate, 24.8% (95% CI 18.0-33.1%), detected in the developed countries. This systematic review is the first to provide an estimate of the prevalence of enteric pathogens associated with diarrhoeal illnesses in adults and children in developed and developing settings. While pathogen detection rate is greater in developing regions the consistently high prevalence of rotavirus in both developed and developing settings underscores the urgent need for access to rotavirus vaccines. Increased travel between developing and developed countries increases disease risk, and hence developed countries have a vested interest in supporting vaccine accessibility in developing settings.
Assessment of Murraya koenigii Leaf Extract against New Multiple Drug Resistance Human Enteric Pathogens. Asian Journal of Chemistry, 32(10), 2647.
EFFECT OF VIRAL GENOME PROPERTY ON THE EFFICIENCY OF VIABILITY (RT-)qPCR. Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research), 76(7), III_189.
Local delivery of macromolecules to treat diseases associated with the colon. Advanced Drug Delivery Reviews, 136-137, 2.
Performance of the QIAstat-Dx Gastrointestinal Panel for Diagnosing Infectious Gastroenteritis. Journal of Clinical Microbiology, 58(3),
Prevalence of Escherichia coli Virulence Genes in Patients with Diarrhea and a Subpopulation of Healthy Volunteers in Madrid, Spain. Frontiers in Microbiology, 7,
Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. 203.
Circulation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai. Scientific Reports, 7(1),
Virus reduction at wastewater treatment plants in Nepal. Environmental Challenges, 5, 100281.
Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis. Journal of Virology, 90(21), 9598.
Development and evaluation of a molecular based protocol for detection and quantification of Cryptosporidium spp. in wastewater. Experimental Parasitology, 234, 108216.
Synthesis of the Heptasaccharide Repeating Unit of the Cell Wall O-Polysaccharide of EnterotoxigenicEscherichia coliO139. ChemistryOpen, 5(1), 43.
Prevalence and drug resistance patterns of Gram-negative enteric bacterial pathogens from diarrheic patients in Ethiopia: A systematic review and meta-analysis. PLOS ONE, 17(3), e0265271.
Food poisoning outbreak in Thailand: A review on situations. Asian Pacific Journal of Tropical Disease, 5, S187.
A 21-year retrospective analysis of environmental impacts on paediatric acute gastroenteritis in an affluent setting. Science of The Total Environment, 764, 142845.
Adenovirüs ve Rotavirüs Gastroenterit Sıklığının Araştırılması. Sağlık Akademisi Kastamonu, 34.
Food Safety in Low and Middle Income Countries. International Journal of Environmental Research and Public Health, 12(9), 10490.
Faecal Pathogen Flows and Their Public Health Risks in Urban Environments: A Proposed Approach to Inform Sanitation Planning. International Journal of Environmental Research and Public Health, 15(2), 181.
Virucidal activity of gamma radiation on strawberries and raspberries. International Journal of Food Microbiology, 304, 89.
Exposure of the Host-Associated Microbiome to Nutrient-Rich Conditions May Lead to Dysbiosis and Disease Development—an Evolutionary Perspective. mBio, 10(3),
Multiplex PCR detection ofCryptosporidiumsp,Giardia lambliaandEntamoeba histolyticadirectly from dried stool samples from Guinea-Bissauan children with diarrhoea. Infectious Diseases, 49(9), 655.
Innate lymphoid cell type 3–derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB. Journal of Biological Chemistry, 294(15), 6027.
Assessing the microbial risk of faecal sludge use in Ugandan agriculture by comparing field and theoretical model output. Water Research, 197, 117068.
Novel multiplex real-time PCR assays reveal a high prevalence of diarrhoeagenic Escherichia coli pathotypes in healthy and diarrhoeal children in the south of Vietnam. BMC Microbiology, 20(1),
Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium. Gut Microbes, 13(1),
Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital. Gut Microbes, 12(1), 1824562.
Food Safety and Preservation. 391.
Commercial Simplex and Multiplex PCR Assays for the Detection of Intestinal Parasites Giardia intestinalis, Entamoeba spp., and Cryptosporidium spp.: Comparative Evaluation of Seven Commercial PCR Kits with Routine In-House Simplex PCR Assays. Microorganisms, 9(11), 2325.
High-dimensional analysis of intestinal immune cells during helminth infection. eLife, 9,
Bacterial travellers’ diarrhoea: A narrative review of literature published over the past 10 years. Travel Medicine and Infectious Disease, 47, 102293.
Food Disgust Scale: Spanish Version. Frontiers in Psychology, 11,
Gastrointestinal Emergencies. 339.
Narrowing of the Diagnostic Gap of Acute Gastroenteritis in Children 0–6 Years of Age Using a Combination of Classical and Molecular Techniques, Delivers Challenges in Syndromic Approach Diagnostics. Pediatric Infectious Disease Journal, 35(9), e262.
High prevalence and prolonged shedding with enteric viruses among children with acute diarrhea in Franceville, Southeast of Gabon. Journal of Clinical Virology Plus, 1(4), 100046.
Molecular and serologic characterization of rotavirus from children with acute gastroenteritis in northern Iran, Gorgan. BMC Gastroenterology, 19(1),
International Clinical Trials in Latin American and Caribbean Countries: Research and Development to Meet Local Health Needs. Frontiers in Pharmacology, 8,
Sensing Food Contaminants: Advances in Analytical Methods and Techniques. Analytical Chemistry, 93(1), 23.
The clinical path to deliver encapsulated phages and lysins. FEMS Microbiology Reviews, 45(5),
Modern Practical Healthcare Issues in Biomedical Instrumentation. 167.
Aetiology and risk factors of bacterial gastroenteritis among febrile outpatients at the Dschang District Hospital, West Region of Cameroon: a cross-sectional study. BMJ Open, 11(9), e045965.
2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine. Cells, 7(12), 225.
Navigating the jungles of tropical infectious gastrointestinal pathology: a pattern-based approach to the endoscopic biopsy. Virchows Archiv, 472(1), 135.
Antibacterial Activity of Bacteriocinogenic Commensal Escherichia coli against Zoonotic Strains Resistant and Sensitive to Antibiotics. Antibiotics, 9(7), 411.
Concurrence of antibiotic resistant bacteria (ARB), viruses, pharmaceuticals and personal care products (PPCPs) in ambient waters of Guwahati, India: Urban vulnerability and resilience perspective. Science of The Total Environment, 693, 133640.
A Systematic Review: The Role of Resident Memory T Cells in Infectious Diseases and Their Relevance for Vaccine Development. Frontiers in Immunology, 9,
Burden of gastrointestinal illness in Sweden-SMS as a tool for collecting self-reported gastrointestinal illness. Epidemiology and Infection, 147,
Convergent Synthesis of the Tetrasaccharide Repeating Unit of the O -Polysaccharide of Salmonella enterica O41. ChemistrySelect, 2(10), 3065.
Detection of Cyclospora in captive chimpanzees and macaques by a quantitative PCR-based mutation scanning approach. Parasites & Vectors, 8(1),
Molecular and epidemiological characterization of human adenoviruses infection among children with acute diarrhea in Shandong Province, China. Virology Journal, 18(1),
Rotavirus infections in children in Turkey: A systematic review. Reviews in Medical Virology, 29(1), e2020.
Monocyte activation, HIV, and cognitive performance in East Africa. Journal of NeuroVirology, 26(1), 52.
Intestinal parasites includingCryptosporidium,Cyclospora,Giardia, andMicrosporidia,Entamoeba histolytica,Strongyloides, Schistosomiasis, andEchinococcus: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation, 33(9),
Human mini-guts: new insights into intestinal physiology and host–pathogen interactions. Nature Reviews Gastroenterology & Hepatology, 13(11), 633.
Vaccine development for enteric bacterial pathogens: Where do we stand?. Pathogens and Disease, 76(5),
Accuracy and Cross-Reactivity of Rapid Diagnostic Tests for Norovirus and Rotavirus in a Real Clinical Setting. Infection & Chemotherapy, 52(3), 360.
Prevalence of intestinal parasitic infections and Campylobacter spp. among children with gastrointestinal disorders in Tehran, Iran. Parasite Epidemiology and Control, 13, e00207.
Seasonal variation and etiologic inferences of childhood pneumonia and diarrhea mortality in India. eLife, 8,
Detection ofSalmonellaspp.,Yersinia enterocolitica,Listeria monocytogenesandCampylobacterspp. by real-time multiplex PCR using amplicon DNA melting analysis and probe-based assay. International Journal of Food Science & Technology, 51(2), 519.
Prevalence of Shigella and Other Pathogenic Gram-negative Bacteria in the Patients with Diarrhea in Kashan City, Iran During 2015-2017 . Journal of Human, Environment, and Health Promotion, 4(3), 106.
Gastrointestinal infection in Italy during the Roman Imperial and Longobard periods: A paleoparasitological analysis of sediment from skeletal remains and sewer drains. International Journal of Paleopathology, 33, 61.
Risk factors for contagious gastroenteritis in adult patients with diarrhoea in the emergency department – a prospective observational multicentre study. BMC Infectious Diseases, 19(1),
Key characteristics of foods with an elevated risk for viral enteropathogen contamination. Journal of Applied Microbiology, 126(4), 996.
Insights intoCampylobacter jejunicolonization of the mammalian intestinal tract using a novel mouse model of infection. Gut Microbes, 6(2), 143.
. Advances in Parasitology, 88, 243.
The epidemiology of non-viral gastroenteritis in New Zealand children from 1997 to 2015: an observational study. BMC Public Health, 19(1),
Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome. Nature Communications, 13(1),
Viral gastroenteritis in hospitalized patients: Evaluation of immunochromatographic methods for rapid detection in stool samples. Journal of Clinical Virology, 128, 104420.
The Ecology and Antibiotic Resistance Patterns of Gastrointestinal Tract Infections in A Tertiary Care Hospital in Oman. Journal of Pure and Applied Microbiology, 15(3), 1634.
Acute Infectious Gastroenteritis in Infancy and Childhood. Deutsches Ärzteblatt international,
Molecular diagnostics of Salmonella and Campylobacter in human/animal fecal samples remain feasible after long-term sample storage without specific requirements. AIMS Microbiology, 7(4), 399.
Resistome and microbial profiling of pediatric patient’s gut infected with multidrug-resistant diarrhoeagenic Enterobacteriaceae using next-generation sequencing; the first study from Pakistan. Libyan Journal of Medicine, 16(1),
DiarrheagenicEscherichia coliandShigellawith High Rate of Extended-Spectrum Beta-Lactamase Production: Two Predominant Etiological Agents of Acute Diarrhea in Shiraz, Iran. Microbial Drug Resistance, 23(8), 1037.
Zakażenia przewodu pokarmowego w XXI wieku w Polsce i na świecie. Postępy Higieny i Medycyny Doświadczalnej, 75(1), 48.
Automated nucleic acids purification from fecal samples on a microfluidic cartridge. BioChip Journal, 11(1), 76.
No Clinical Benefit of Empirical Antimicrobial Therapy for Pediatric Diarrhea in a High-Usage, High-Resistance Setting. Clinical Infectious Diseases, 66(4), 504.
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children. Scientific Reports, 9(1),