Sociodemographic and clinical factors associated with cryptorchidism in live births in Brazil: a 20-year analysis

  • Diego Bessa Dantas
    School of Physiotherapy and Occupational Therapy, Federal University of Pará (UFPA), Belém, Brazil.
  • Dionata da Costa
    School of Physiotherapy and Occupational Therapy, Federal University of Pará (UFPA), Belém, Brazil.
  • Edila Andrade
    School of Physiotherapy and Occupational Therapy, Federal University of Pará (UFPA), Belém, Brazil.
  • Maria do Socorro Bastos
    School of Physiotherapy and Occupational Therapy, Federal University of Pará (UFPA), Belém, Brazil.
  • Fabiana Gomes
    School of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.
  • João Simão de Melo-Neto
    School of Physiotherapy and Occupational Therapy, Federal University of Pará (UFPA), Belém, Brazil.


Background: Cryptorchidism is a congenital disorder that causes an irregularity in the permanent or temporary descent of one or both testicles. In Brazil, there are no comprehensive studies describing the association of demographic, social, and clinical characteristics in relation to cryptorchidism.
Objectives: This study aims to verify possible associations of clinical and sociodemographic characteristics in patients with cryptorchidism.
Design and Methods: An analytical, descriptive and retrospective study was carried out based on secondary data of 5,168 live births with cryptorchidism recorded in the Live Birth Information System (SINASC), Brazil from 1999 to 2018. The socio-demographic factors analyzed were the geographic region, age, education and marital status of the mothers. The clinical factors analyzed were the duration and type of pregnancy. The place of birth was also analyzed as a secondary outcome.
Results: This research analyzed all live births during the study period, in Brazil. The chance of cryptorchidism in the neonate is more common in women who become pregnant later (≥30 years of age) and with a higher level of education (≥8 years). The risk of cryptorchidism in relation to the federation units is higher in Paraíba, Pernambuco, Sergipe, São Paulo, and Santa Catarina. Regarding the clinical characteristics, the shorter pregnancies, which characterize premature births, are a risk for the appearance of cryptorchidism in the country.
Conclusion: Thus, in this study, we found that sociodemographic and clinical factors have specific characteristics that predict cryptorchidism in newborns in Brazil.


Rodprasert W, Virtanen HE, Mäkelä J.A, Toppari J. Hypogonadism and cryptorchidism. Front Endocrinol 2020;10:906. DOI:

Huff DS, Fenig DM, Canning DA, et al. Abnormal germ cell development in cryptorchidism. Horm Res 2001;55:11-7. DOI:

Dong LH, Hildorf S, Clasen-Linde E, et al. Postnatal germ cell development in cryptorchid boys. Asian J Androl 2020;22:258-64. DOI:

Gurney JK, McGlynn KA, Stanley J, et al. Risk factors for cryptorchidism. Nat Rev Urol 2017;14:534-48. DOI:

Barthold JS, Reinhardt S, Thorup J. Genetic, Maternal, and environmental risk factors for cryptorchidism: An update. Eur J Pediatr Surg 2016;26:399-408. DOI:

Virtanen HE, Toppari J. Epidemiology and pathogenesis of cryptorchidism. Hum Reprod Update 2008;14:49-58. DOI:

Désiré AM, Buhendwa C, Césaire TMA, et al. Epidemiology, diagnosis and therapeutic approaches of cryptorchidism at the Panzi General Hospital, DR Congo: A 5-year retrospective study. Ethiop J Health Sci 2020;30:107-14.

Cremonese C, Freire C, Meyer A, Koifman S. [Pesticide exposure and adverse pregnancy events, Southern Brazil, 1996-2000].[Article in Portuguese]. Cad Saude Publica 2012;28:1263-72. DOI:

Asmus CIRF, Camara VM, Landrigan PJ, Claudio LA. Systematic review of children's environmental health in Brazil. Ann Global Health 2016;82:132-48. DOI:

Ministry of Health, Executive Secretariat. DATASUS, Health Information. Available from:

Pignati WA, Lima FANS, Lara SS, et al. [Spatial distribution of pesticide use in Brazil: a strategy for Health Surveillance].[Article in Portuguese, En]. Cien Saude Colet 2017;22:3281-93. DOI:

Domingues RMSM, Figueiredo VC, Leal MDC. Prevalence of pre-gestational and gestational smoking and factors associated with smoking cessation during pregnancy, Brazil, 2011-2012. PLoS One 2019;14:e0217397. DOI:

Russo F.B, Jungmann P, Beltrão-Braga P.C.B. Zika infection and the development of neurological defects. Cell Microbiol 2017;19. doi: 10.1111/cmi.12744/

De Vasconcelos RAL, Ximenes RAA, Calado AA, et al. Cryptorchidism in children with Zika-related microcephaly. Am J Trop Med Hyg 2020;102:982-4. DOI:

McGlynn KA, Graubard BI, Klebanoff MA, Longnecker MP. Risk factors for cryptorchidism among populations at differing risks of testicular cancer. Int J Epidemiol 2006;35:787-95. DOI:

Biney AAE, Nyarko P. Is a woman's first pregnancy outcome related to her years of schooling? An assessment of women's adolescent pregnancy outcomes and subsequent educational attainment in Ghana. Reprod Health 2017;14:123. DOI:

Hutson JM, Balic A, Nation T, Southwell B. Cryptorchidism. Semin Pediatr Surg 2010;19:215-24. DOI:

Timoteo F, Korkes F, Baccaglini W, Glina S. Bladder cancer trends and mortality in the Brazilian public health system. Int Braz J Urol 2020;46:224-33. DOI: