Background: Cryptorchidism is a congenital disorder that causes an irregularity in the permanent or temporary descent of one or both testicles. In Brazil, there are no comprehensive studies describing the association of demographic, social, and clinical characteristics in relation to cryptorchidism.
Objectives: This study aims to verify possible associations of clinical and sociodemographic characteristics in patients with cryptorchidism.
Design and Methods: An analytical, descriptive and retrospective study was carried out based on secondary data of 5,168 live births with cryptorchidism recorded in the Live Birth Information System (SINASC), Brazil from 1999 to 2018. The socio-demographic factors analyzed were the geographic region, age, education and marital status of the mothers. The clinical factors analyzed were the duration and type of pregnancy. The place of birth was also analyzed as a secondary outcome.
Results: This research analyzed all live births during the study period, in Brazil. The chance of cryptorchidism in the neonate is more common in women who become pregnant later (≥30 years of age) and with a higher level of education (≥8 years). The risk of cryptorchidism in relation to the federation units is higher in Paraíba, Pernambuco, Sergipe, São Paulo, and Santa Catarina. Regarding the clinical characteristics, the shorter pregnancies, which characterize premature births, are a risk for the appearance of cryptorchidism in the country.
Conclusion: Thus, in this study, we found that sociodemographic and clinical factors have specific characteristics that predict cryptorchidism in newborns in Brazil.
Rodprasert W, Virtanen HE, Mäkelä J.A, Toppari J. Hypogonadism and cryptorchidism. Front Endocrinol 2020;10:906. DOI: https://doi.org/10.3389/fendo.2019.00906
Huff DS, Fenig DM, Canning DA, et al. Abnormal germ cell development in cryptorchidism. Horm Res 2001;55:11-7. DOI: https://doi.org/10.1159/000049957
Dong LH, Hildorf S, Clasen-Linde E, et al. Postnatal germ cell development in cryptorchid boys. Asian J Androl 2020;22:258-64. DOI: https://doi.org/10.4103/aja.aja_48_19
Gurney JK, McGlynn KA, Stanley J, et al. Risk factors for cryptorchidism. Nat Rev Urol 2017;14:534-48. DOI: https://doi.org/10.1038/nrurol.2017.90
Barthold JS, Reinhardt S, Thorup J. Genetic, Maternal, and environmental risk factors for cryptorchidism: An update. Eur J Pediatr Surg 2016;26:399-408. DOI: https://doi.org/10.1055/s-0036-1592416
Virtanen HE, Toppari J. Epidemiology and pathogenesis of cryptorchidism. Hum Reprod Update 2008;14:49-58. DOI: https://doi.org/10.1093/humupd/dmm027
Désiré AM, Buhendwa C, Césaire TMA, et al. Epidemiology, diagnosis and therapeutic approaches of cryptorchidism at the Panzi General Hospital, DR Congo: A 5-year retrospective study. Ethiop J Health Sci 2020;30:107-14.
Cremonese C, Freire C, Meyer A, Koifman S. [Pesticide exposure and adverse pregnancy events, Southern Brazil, 1996-2000].[Article in Portuguese]. Cad Saude Publica 2012;28:1263-72. DOI: https://doi.org/10.1590/S0102-311X2012000700005
Asmus CIRF, Camara VM, Landrigan PJ, Claudio LA. Systematic review of children's environmental health in Brazil. Ann Global Health 2016;82:132-48. DOI: https://doi.org/10.1016/j.aogh.2016.02.007
Ministry of Health, Executive Secretariat. DATASUS, Health Information. Available from: http://www2.datasus.gov.br/DATASUS/index.php?area=0205
Pignati WA, Lima FANS, Lara SS, et al. [Spatial distribution of pesticide use in Brazil: a strategy for Health Surveillance].[Article in Portuguese, En]. Cien Saude Colet 2017;22:3281-93. DOI: https://doi.org/10.1590/1413-812320172210.17742017
Domingues RMSM, Figueiredo VC, Leal MDC. Prevalence of pre-gestational and gestational smoking and factors associated with smoking cessation during pregnancy, Brazil, 2011-2012. PLoS One 2019;14:e0217397. DOI: https://doi.org/10.1371/journal.pone.0217397
Russo F.B, Jungmann P, Beltrão-Braga P.C.B. Zika infection and the development of neurological defects. Cell Microbiol 2017;19. doi: 10.1111/cmi.12744/
De Vasconcelos RAL, Ximenes RAA, Calado AA, et al. Cryptorchidism in children with Zika-related microcephaly. Am J Trop Med Hyg 2020;102:982-4. DOI: https://doi.org/10.4269/ajtmh.19-0753
McGlynn KA, Graubard BI, Klebanoff MA, Longnecker MP. Risk factors for cryptorchidism among populations at differing risks of testicular cancer. Int J Epidemiol 2006;35:787-95. DOI: https://doi.org/10.1093/ije/dyl024
Biney AAE, Nyarko P. Is a woman's first pregnancy outcome related to her years of schooling? An assessment of women's adolescent pregnancy outcomes and subsequent educational attainment in Ghana. Reprod Health 2017;14:123. DOI: https://doi.org/10.1186/s12978-017-0378-2
Hutson JM, Balic A, Nation T, Southwell B. Cryptorchidism. Semin Pediatr Surg 2010;19:215-24. DOI: https://doi.org/10.1053/j.sempedsurg.2010.04.001
Timoteo F, Korkes F, Baccaglini W, Glina S. Bladder cancer trends and mortality in the Brazilian public health system. Int Braz J Urol 2020;46:224-33. DOI: https://doi.org/10.1590/s1677-5538.ibju.2019.0198