In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol

  • Tricia L. Larose | tricia.larose@ntnu.no K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Pål Sætrom 1K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Computer Science, Faculty of Information Technology and Electrical Engineering, Norwegian University of Science and Technology, Trondheim; Bioinformatics core facility – BioCore, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Marit P. Martinussen Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Håkon Skogseth Biobank 1, St. Olavs University Hospital, Trondheim, Norway.
  • Torkjel M. Sandanger Department of Community Medicine, Faculty of Health Sciences, UiT-the Arctic University of Norway, Tromsø, Norway.
  • Ghislaine Scelo Genetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Cliona M. McHale Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.
  • Geir W. Jacobsen Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
  • Martyn T. Smith Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.

Abstract

Background: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).
Methods/design: This pilot study includes pregnant women at high risk (smoking at conception), and low risk (non-smoking at conception) for SGA birth (birthweight<10th percentile for gestational age). We have randomly selected 12 mothers (3 high-risk SGA birth, 3 low-risk SGA birth, 3 high-risk non-SGA birth, 3 low-risk non-SGA birth), with EDC measurements from gestational week 17. All offspring are female. We aim to test the stability of our samples (maternal serum, cord blood, placenta tissue), observe the differential expression of miRNA profiles over time (gestational weeks 17, 25, 33, 37, birth), and study the consistency between maternal EDC measures and miRNA expression profiles across our repeated measures.
Expected impact of the study for Public Health: Results from this pilot study will inform the development of a larger cohort wide analysis, and will impact the current state of knowledge in the fields of public health, epigenetics, and the DOHaD.

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Published
2019-09-05
Info
Issue
Section
Study Protocols
Supporting Agencies
Peder Sather Center for Advanced Studies Grant Program
Keywords:
environmental health, endocrine disrupting chemicals, fetal growth, miRNA
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How to Cite
Larose, T. L., Sætrom, P., Martinussen, M. P., Skogseth, H., Sandanger, T. M., Scelo, G., McHale, C. M., Jacobsen, G. W., & Smith, M. T. (2019). In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol. Journal of Public Health Research, 8(2). https://doi.org/10.4081/jphr.2019.1550